EHP.net: Regional Workbench

EHPnet.

After attending the sarcoma session of the 1990 meeting of the American Society for Clinical Oncology, one might be forgiven for wondering if chemotherapy for metastatic soft tissue sarcoma (STS) has come a full circle. It is 18 years since the South West Oncology Group (SWOG) published results of the first large scale study of doxorubicin (ADR) (O'Bryan et al., 1973). In 45 evaluable patients ...

EHPnet: www.fueleconomy.gov

Background: Myostatin, a muscle-specific member of the Transforming Growth Factor beta family, negatively regulates muscle development. Double-muscled (DM) cattle have a loss-offunction mutation in their myostatin gene responsible for the hypermuscular phenotype. Thus, these animals are a good model for understanding the mechanisms underpinning muscular hypertrophy. In order to identify individ...

EHPnet: Bioremediation

Background: 18F-FLT is a novel PET radiotracer which has demonstrated a strong potential utility for imaging cellular proliferation in human tumors in vivo. To facilitate future regulatory approval of 18F-FLT for clinical use, we wished to demonstrate the safety of radiotracer doses of 18F-FLT administered to human subjects, by: 1) performing an evaluation of the toxicity of 18F-FLT administere...

EHPnet: Genetic Toolbox

EHPnet: Silicon Lungs

Background: To evaluate the effectiveness and safety of the support given to women by a companion of their choice during labor and delivery. Methods: A total of 212 primiparous women were enrolled in a randomized controlled clinical trial carried out between February 2004 and March 2005. One hundred and five women were allocated to the group in which support was permitted and 107 to the group i...